Purged modemmanager and now I'm running full throttle on an Ubuntu 14.04 installation. I started out with ISE running on a virtual copy of Win7 and using the Windows bitloader. Took forever to upload the bitstream for some reason. Reinstalled everything on Linux and got this last bit working as well. Code: sudo apt-get install python3-serial sudo apt-get purge modemmanager Also changed the first line of the script: Code: #! /usr/local/env python3 and put it in /usr/local/bin Works beautifully.